Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5345701

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HEV Kernow-C1 infected in gaussia luciferase transfected HepG2 cells assessed as reduction in viral replication pre-infected with virus for 4 hrs followed by compound addition and measured after 48 hrs post infection by luminometer analysis
ChEMBL ↗
62
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis E virus
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis E virus (CHEMBL5465478) ↗
Type ORGANISM
Organism Hepatitis E virus

Publication

Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses.
Victoria C, Schulz G, Klöhn M, Weber S, Holicki CM, Brüggemann Y, Becker M, Gerold G, Eiden M, Groschup MH, Steinmann E, Kirschning A.
J Med Chem (2024) 67 : 289 -321
PubMed 38127656 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 31 7.76 9.70
EC90 31 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5426340 — — 2 9.70
CHEMBL5410538 — — 2 8.85
CHEMBL555196 SILVESTROL — 2 8.66
CHEMBL5427607 — — 2 8.64
CHEMBL2170557 — — 2 8.60
CHEMBL5430519 — — 2 8.59
CHEMBL2058177 — — 2 8.43
CHEMBL5419804 — — 2 8.26
CHEMBL5440254 — — 2 8.05
CHEMBL1651415 — — 2 8.03
CHEMBL5419893 — — 2 8.01
CHEMBL5400342 — — 2 7.96
CHEMBL5410759 — — 2 7.83
CHEMBL5406130 — — 2 7.83
CHEMBL2179344 — — 2 7.78
CHEMBL5415090 — — 2 7.76
CHEMBL438139 ROCAGLAMIDE — 2 7.68
CHEMBL394528 AGLAFOLIN — 2 7.52
CHEMBL5420371 — — 2 7.48
CHEMBL5429795 — — 2 7.42
CHEMBL5402242 — — 2 7.35
CHEMBL5436577 — — 2 7.33
CHEMBL5394409 — — 2 7.28
CHEMBL5405020 — — 2 7.20
CHEMBL5408716 — — 2 7.19
CHEMBL5404815 — — 2 7.12
CHEMBL5419469 — — 2 6.83
CHEMBL5427386 — — 2 6.68
CHEMBL5423958 — — 2 6.48
CHEMBL5410798 — — 2 6.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5426340 — EC50 = 0.2 nM 9.70
CHEMBL5410538 — EC50 = 1.4 nM 8.85
CHEMBL555196 SILVESTROL EC50 = 2.2 nM 8.66
CHEMBL5427607 — EC50 = 2.3 nM 8.64
CHEMBL2170557 — EC50 = 2.5 nM 8.60
CHEMBL5430519 — EC50 = 2.6 nM 8.59
CHEMBL2058177 — EC50 = 3.7 nM 8.43
CHEMBL5419804 — EC50 = 5.5 nM 8.26
CHEMBL5440254 — EC50 = 8.9 nM 8.05
CHEMBL1651415 — EC50 = 9.4 nM 8.03
CHEMBL5419893 — EC50 = 9.8 nM 8.01
CHEMBL5400342 — EC50 = 10.9 nM 7.96
CHEMBL5410759 — EC50 = 14.9 nM 7.83
CHEMBL5406130 — EC50 = 14.7 nM 7.83
CHEMBL2179344 — EC50 = 16.8 nM 7.78
CHEMBL5415090 — EC50 = 17.5 nM 7.76
CHEMBL438139 ROCAGLAMIDE EC50 = 21.0 nM 7.68
CHEMBL394528 AGLAFOLIN EC50 = 29.9 nM 7.52
CHEMBL5420371 — EC50 = 33.2 nM 7.48
CHEMBL5429795 — EC50 = 37.9 nM 7.42
CHEMBL5402242 — EC50 = 44.7 nM 7.35
CHEMBL5436577 — EC50 = 47.1 nM 7.33
CHEMBL5394409 — EC50 = 52.9 nM 7.28
CHEMBL5405020 — EC50 = 63.2 nM 7.20
CHEMBL5408716 — EC50 = 64.3 nM 7.19
CHEMBL5404815 — EC50 = 75.7 nM 7.12
CHEMBL5419469 — EC50 = 146.1 nM 6.83
CHEMBL5427386 — EC50 = 208.2 nM 6.68
CHEMBL5423958 — EC50 = 334.3 nM 6.48
CHEMBL5410798 — EC50 = 731.7 nM 6.14
CHEMBL5394409 — EC90 = 338.2 nM -
CHEMBL5419893 — EC90 = 134.5 nM -
CHEMBL1651415 — EC90 = 91.3 nM -
CHEMBL5429795 — EC90 = 364.6 nM -
CHEMBL5401157 — EC90 > 1000.0 nM -
CHEMBL5410798 — EC90 > 1000.0 nM -
CHEMBL5423958 — EC90 > 1000.0 nM -
CHEMBL5427386 — EC90 = 828.8 nM -
CHEMBL5419469 — EC90 = 873.3 nM -
CHEMBL5404815 — EC90 = 393.5 nM -
CHEMBL5405020 — EC90 = 298.0 nM -
CHEMBL438139 ROCAGLAMIDE EC90 = 201.3 nM -
CHEMBL2179344 — EC90 = 105.4 nM -
CHEMBL394528 AGLAFOLIN EC90 = 187.8 nM -
CHEMBL5400342 — EC90 = 69.8 nM -
CHEMBL5402242 — EC90 = 304.7 nM -
CHEMBL5408716 — EC90 = 633.7 nM -
CHEMBL5420371 — EC90 = 282.4 nM -
CHEMBL5440254 — EC90 = 101.6 nM -
CHEMBL5436577 — EC90 = 758.7 nM -