Assay Detail
Functional
CHEMBL5345703
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Antiviral activity against Chikungunya virus ECSA infected in Huh-7 cells expressing GFP assessed as reduction in viral replication pre-infected with virus for 1 hr followed by compound addition and measured after 24 hrs post infection by fluorescence based assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chikungunya virus |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.31 | 8.68 |
| EC90 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410538 | — | — | 2 | 8.68 |
| CHEMBL5430519 | — | — | 2 | 8.51 |
| CHEMBL5415090 | — | — | 2 | 7.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410538 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5430519 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5415090 | — | EC50 | = | 18.1 | nM | 7.74 |
| CHEMBL5410538 | — | EC90 | = | 12.3 | nM | - |
| CHEMBL5415090 | — | EC90 | = | 83.4 | nM | - |
| CHEMBL5430519 | — | EC90 | = | 19.0 | nM | - |