Assay Detail
Functional
CHEMBL5345709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 2019-nCoV Muc-IMB-1 infected in Vero E6 cells assessed as reduction in viral replication pre-infected with virus for 1 hr followed by compound addition and measured after 48 hrs post infection by RT-qPCR analysis
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.93 | 7.32 |
| EC90 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410538 | — | — | 2 | 7.32 |
| CHEMBL5415090 | — | — | 2 | 6.75 |
| CHEMBL5430519 | — | — | 2 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410538 | — | EC50 | = | 47.8 | nM | 7.32 |
| CHEMBL5415090 | — | EC50 | = | 176.5 | nM | 6.75 |
| CHEMBL5430519 | — | EC50 | = | 189.5 | nM | 6.72 |
| CHEMBL5410538 | — | EC90 | = | 80.0 | nM | - |
| CHEMBL5415090 | — | EC90 | = | 557.5 | nM | - |
| CHEMBL5430519 | — | EC90 | = | 339.9 | nM | - |