Assay Detail
Functional
CHEMBL5346221
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Cytotoxicity against human hormone nonresponsive PC-3 cells assessed as reduction in cell proliferation by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Homodimer of Withaferin A Formed by Base-Promoted Elimination of Acetic Acid from 27-<i>O</i>-Acetylwithaferin A Followed by a Diels-Alder Reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.31 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5401906 | — | — | 1 | 6.70 |
| CHEMBL5406288 | — | — | 1 | 6.70 |
| CHEMBL2047407 | — | — | 1 | 6.52 |
| CHEMBL5403691 | — | — | 1 | 6.40 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.22 |
| CHEMBL5404628 | — | — | 1 | 6.00 |
| CHEMBL5408627 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5401906 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5406288 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2047407 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5403691 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5404628 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5408627 | — | IC50 | = | 2200.0 | nM | 5.66 |