Assay Detail
Toxicity
CHEMBL5346222
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Cytotoxicity against human HFF cells assessed as reduction in cell proliferation by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Homodimer of Withaferin A Formed by Base-Promoted Elimination of Acetic Acid from 27-<i>O</i>-Acetylwithaferin A Followed by a Diels-Alder Reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.90 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406288 | — | — | 1 | 6.30 |
| CHEMBL5401906 | — | — | 1 | 6.22 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.85 |
| CHEMBL2047407 | — | — | 1 | 5.72 |
| CHEMBL5403691 | — | — | 1 | 5.70 |
| CHEMBL5404628 | — | — | 1 | 5.60 |
| CHEMBL5408627 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406288 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5401906 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2047407 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5403691 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5404628 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5408627 | — | IC50 | > | 5000.0 | nM | - |