Assay Detail
Functional
CHEMBL5346485
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Agonist activity at human smBiT-fused 5HT2A receptor expressed in CHO-K1 cells co-expressing IgBiT-fused beta-arrestin2 assessed as beta-arrestin2 recruitment by measuring increase in chemiluminescence intensity incubated for 2 hrs by NanoBiT luciferase assay
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pioneering Methods in Brain Optimization and Mental Health Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.96 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4648350 | — | — | 2 | 8.62 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 8.14 |
| CHEMBL263881 | LYSERGIDE | 2.0 | 2 | 7.80 |
| CHEMBL65547 | PSILOCIN | 2.0 | 2 | 7.70 |
| CHEMBL39 | SEROTONIN | 3.0 | 2 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4648350 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4648350 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL442 | ERGOTAMINE | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL442 | ERGOTAMINE | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL263881 | LYSERGIDE | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL263881 | LYSERGIDE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL65547 | PSILOCIN | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL65547 | PSILOCIN | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL39 | SEROTONIN | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL39 | SEROTONIN | EC50 | = | 28.0 | nM | 7.55 |