Assay Detail
Binding
CHEMBL5346522
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Inhibition of human DHODH in MOLM-13 AML cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.88 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180161 | — | — | 1 | 9.62 |
| CHEMBL5193821 | — | — | 1 | 9.52 |
| CHEMBL5419877 | — | — | 1 | 8.85 |
| CHEMBL5409064 | — | — | 1 | 8.64 |
| CHEMBL5409267 | — | — | 1 | 8.62 |
| CHEMBL5407738 | — | — | 1 | 8.55 |
| CHEMBL5428012 | — | — | 1 | 8.46 |
| CHEMBL5407486 | — | — | 1 | 8.42 |
| CHEMBL5405721 | — | — | 1 | 8.40 |
| CHEMBL5398296 | — | — | 1 | 8.39 |
| CHEMBL5432814 | — | — | 1 | 8.27 |
| CHEMBL5421552 | — | — | 1 | 8.22 |
| CHEMBL5427450 | — | — | 1 | 8.05 |
| CHEMBL5399532 | — | — | 1 | 7.89 |
| CHEMBL5439442 | — | — | 1 | 7.52 |
| CHEMBL5423878 | — | — | 1 | 7.40 |
| CHEMBL5403590 | — | — | 1 | 7.32 |
| CHEMBL5439460 | — | — | 1 | 7.24 |
| CHEMBL5395154 | — | — | 1 | 7.00 |
| CHEMBL5399005 | — | — | 1 | 7.00 |
| CHEMBL5404114 | — | — | 1 | 6.80 |
| CHEMBL5421173 | — | — | 1 | 6.65 |
| CHEMBL5426062 | — | — | 1 | 6.22 |
| CHEMBL5393795 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180161 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL5193821 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5419877 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5409064 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5409267 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5407738 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5428012 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5407486 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5405721 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5398296 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5432814 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5421552 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5427450 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5399532 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5439442 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5423878 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5403590 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5439460 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5395154 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5399005 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5404114 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5421173 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL5426062 | — | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL5393795 | — | IC50 | = | 1040.0 | nM | 5.98 |