Assay Detail
Binding
CHEMBL5346988
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant epitope tagged JAK2 (unknown origin) (828 to 1132 residues) using peptide as substrate in presence of ATP by homogeneous time-resolved fluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.24 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | IC50 | = | 5.7 | nM | 8.24 |