Assay Detail
Binding
CHEMBL5347111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P-gp1 efflux in human Flp-In-293 cells using rhodamine as substrate assessed as increase in intracellular accumulation of rhodamine 123 preincubated for 30 mins followed by substrate addition and measured for 10 mins by fluorescence based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Flp-In-293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.81 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105360 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105360 | — | IC50 | = | 1560.0 | nM | 5.81 |