Assay Detail
Functional
CHEMBL5347119
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Reversal of paclitaxel resistance in human Flp-In-293 cells expressing ABCB1 assessed as cell growth inhibition in presence of caffeic acid for 30 mins by fluorescence based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Flp-In-293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.91 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 124.55 | nM | 6.91 |