Assay Detail

CHEMBL5347120

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Functional

Reversal of doxorubicin resistance in human Flp-In-293 cells expressing ABCB1 assessed as cell growth inhibition in presence of caffeic acid for 30 mins by fluorescence based assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Flp-In-293
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.

Engle K, Kumar G.
Eur J Med Chem (2022) 239 : 114542 -114542
PubMed 35751979 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.22	6.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL145	CAFFEIC ACID	3.0	1	6.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL145	CAFFEIC ACID	IC50	=	596.9	nM	6.22