Assay Detail
Binding
CHEMBL5347351
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P13Kgamma (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.89 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3984425 | EGANELISIB | 2.0 | 1 | 9.54 |
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 9.15 |
| CHEMBL3544966 | GSK-1059615 | 1.0 | 1 | 8.30 |
| CHEMBL4126156 | — | — | 1 | 8.10 |
| CHEMBL3545366 | VOXTALISIB | 2.0 | 1 | 8.05 |
| CHEMBL3813842 | PAXALISIB | 2.0 | 1 | 8.00 |
| CHEMBL5278435 | — | — | 1 | 7.89 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 7.85 |
| CHEMBL4297181 | SAMOTOLISIB | 2.0 | 1 | 7.62 |
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 7.60 |
| CHEMBL2064571 | — | — | 1 | 7.57 |
| CHEMBL4297584 | TENALISIB | 2.0 | 1 | 7.48 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.31 |
| CHEMBL3039502 | DUVELISIB | 4.0 | 1 | 7.30 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3984425 | EGANELISIB | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL3218576 | COPANLISIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3544966 | GSK-1059615 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4126156 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3545366 | VOXTALISIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3813842 | PAXALISIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5278435 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4297181 | SAMOTOLISIB | IC50 | = | 23.8 | nM | 7.62 |
| CHEMBL3393066 | VS-5584 | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2064571 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4297584 | TENALISIB | IC50 | = | 33.2 | nM | 7.48 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3039502 | DUVELISIB | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 262.0 | nM | 6.58 |