Assay Detail
Binding
CHEMBL5347363
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKBgamma (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.27 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428462 | — | — | 1 | 7.33 |
| CHEMBL3544960 | AT-13148 | 1.0 | 1 | 7.30 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 7.19 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428462 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3544960 | AT-13148 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2325741 | CAPIVASERTIB | IC50 | <= | 8.0 | nM | - |