Assay Detail
Binding
CHEMBL5347377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant mTOR (unknown origin) using (4eBP1)26 as substrate incubated for 1 hrs in the presence of ATP by [gamma33P]ATP based scintillation counting analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.43 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393066 | VS-5584 | IC50 | = | 37.0 | nM | 7.43 |