Assay Detail
Functional
CHEMBL5347953
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Antiviral activity against Canine coronavirus infected in CRFK cells assessed as reduction in viral copy pre-infected with cells for 1 hrs followed by compound addition and measured after 48 hrs by RT-qPCR analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canine coronavirus |
| Cell Type | CRFK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.74 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 5.89 |
| CHEMBL5431971 | — | — | 1 | 5.85 |
| CHEMBL5414409 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016757 | GS-441524 | EC50 | = | 1295.0 | nM | 5.89 |
| CHEMBL5431971 | — | EC50 | = | 1406.0 | nM | 5.85 |
| CHEMBL5414409 | — | EC50 | = | 3214.0 | nM | 5.49 |