Assay Detail
Binding
CHEMBL5348278
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protac activity at VHL/LSD1/HDAC2/CoREST complex interaction in human ES1 cells assessed as induction of HDAC2 degradation by fluorescence based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | ES1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor/LSD1/HDAC2/RCOR1 (CHEMBL5483007) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Developments of PROTACs technology in immune-related diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5073757 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5073757 | — | IC50 | = | 500.0 | nM | 6.30 |