Assay Detail
Binding
CHEMBL5348484
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Binding affinity to histamine H4 receptor (unknown origin) assessed as inhibition constant
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Treatment of allergy: Overview of synthetic anti-allergy small molecules in medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.71 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | — | 1 | 8.39 |
| CHEMBL493720 | — | — | 1 | 8.32 |
| CHEMBL129660 | — | — | 1 | 8.31 |
| CHEMBL3301609 | TOREFORANT | 2.0 | 1 | 8.08 |
| CHEMBL3290570 | — | — | 1 | 8.00 |
| CHEMBL185951 | — | — | 1 | 7.57 |
| CHEMBL3290576 | — | — | 1 | 6.69 |
| CHEMBL3290578 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL493720 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL129660 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL3301609 | TOREFORANT | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL3290570 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL185951 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3290576 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL3290578 | — | Ki | = | 524.0 | nM | 6.28 |