Assay Detail
Functional
CHEMBL5349012
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Antiproliferative activity against human NALM-16 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NALM-16 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.59 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5432745 | — | — | 1 | 8.52 |
| CHEMBL5439607 | — | — | 1 | 8.22 |
| CHEMBL5422163 | — | — | 1 | 8.15 |
| CHEMBL5400310 | — | — | 1 | 8.15 |
| CHEMBL5440537 | — | — | 1 | 7.92 |
| CHEMBL3581647 | BIRABRESIB | 2.0 | 1 | 7.85 |
| CHEMBL5420752 | — | — | 1 | 7.85 |
| CHEMBL5436475 | — | — | 1 | 7.85 |
| CHEMBL5424952 | — | — | 1 | 7.80 |
| CHEMBL1957266 | — | — | 1 | 7.75 |
| CHEMBL5403848 | — | — | 1 | 7.03 |
| CHEMBL5398000 | — | — | 1 | 6.76 |
| CHEMBL5401253 | — | — | 1 | 6.34 |
| CHEMBL5399489 | — | — | 1 | 6.10 |
| CHEMBL5440963 | — | — | 1 | - |
| CHEMBL5422881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5432745 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5439607 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5422163 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5400310 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5440537 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3581647 | BIRABRESIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5420752 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5436475 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5424952 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1957266 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5403848 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5398000 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL5401253 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL5399489 | — | IC50 | = | 791.0 | nM | 6.10 |
| CHEMBL5440963 | — | IC50 | = | - | nM | - |
| CHEMBL5422881 | — | IC50 | > | 8848.0 | nM | - |