Assay Detail
Binding
CHEMBL5349109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant LSD1 (unknown origin) expressed in Escherichia coli BL21(DE3) strain using H3K4me2 peptide as substrate incubated for 30 mins by fluorescence based analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of acridine-based LSD1 inhibitors as immune activators targeting LSD1 in gastric cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.19 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106525 | — | — | 1 | 7.14 |
| CHEMBL5415964 | — | — | 1 | 7.07 |
| CHEMBL5416497 | — | — | 1 | 7.00 |
| CHEMBL217366 | — | — | 1 | 6.96 |
| CHEMBL5404489 | — | — | 1 | 6.89 |
| CHEMBL5419169 | — | — | 1 | 6.85 |
| CHEMBL322748 | — | — | 1 | 6.66 |
| CHEMBL5416205 | — | — | 1 | 6.64 |
| CHEMBL5440680 | — | — | 1 | 6.64 |
| CHEMBL5421422 | — | — | 1 | 6.55 |
| CHEMBL5412335 | — | — | 1 | 6.35 |
| CHEMBL289352 | — | — | 1 | 6.22 |
| CHEMBL9806 | — | — | 1 | 6.18 |
| CHEMBL5430017 | — | — | 1 | 6.16 |
| CHEMBL5415883 | — | — | 1 | 6.15 |
| CHEMBL5411051 | — | — | 1 | 6.13 |
| CHEMBL5431065 | — | — | 1 | 6.07 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.06 |
| CHEMBL1964647 | — | — | 1 | 6.01 |
| CHEMBL49436 | — | — | 1 | 5.98 |
| CHEMBL52101 | — | — | 1 | 5.94 |
| CHEMBL5396199 | — | — | 1 | 5.78 |
| CHEMBL5407377 | — | — | 1 | 5.76 |
| CHEMBL5417480 | — | — | 1 | 5.62 |
| CHEMBL22062 | — | — | 1 | 5.45 |
| CHEMBL51599 | — | — | 1 | 5.44 |
| CHEMBL5413825 | — | — | 1 | 5.41 |
| CHEMBL5420365 | — | — | 1 | 5.22 |
| CHEMBL433078 | — | — | 1 | 5.08 |
| CHEMBL5437914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106525 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5415964 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5416497 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL217366 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5404489 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5419169 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL322748 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5416205 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5440680 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5421422 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5412335 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL289352 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL9806 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5430017 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5415883 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5411051 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5431065 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL43 | AMSACRINE | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL1964647 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL49436 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL52101 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5396199 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL5407377 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL5417480 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL22062 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL51599 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL5413825 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL5420365 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL433078 | — | IC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL5437914 | — | IC50 | - | — | - | |
| CHEMBL5432181 | — | IC50 | - | — | - | |
| CHEMBL5430268 | — | IC50 | - | — | - | |
| CHEMBL5420807 | — | IC50 | - | — | - | |
| CHEMBL48150 | — | IC50 | - | — | - | |
| CHEMBL5402084 | — | IC50 | - | — | - | |
| CHEMBL5440613 | — | IC50 | - | — | - | |
| CHEMBL295949 | — | IC50 | - | — | - |