Assay Detail
Functional
CHEMBL5349604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CD4+ve Th |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.26 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5440411 | — | — | 1 | 6.37 |
| CHEMBL5434552 | — | — | 1 | 6.37 |
| CHEMBL5427907 | — | — | 1 | 5.93 |
| CHEMBL5394402 | — | — | 1 | 5.78 |
| CHEMBL5407300 | — | — | 1 | 5.64 |
| CHEMBL5173775 | — | — | 1 | 5.61 |
| CHEMBL216981 | NAVARIXIN ANHYDROUS | 2.0 | 1 | 5.33 |
| CHEMBL5409816 | — | — | 1 | 5.28 |
| CHEMBL5405321 | — | — | 1 | 5.25 |
| CHEMBL5411713 | — | — | 1 | 5.24 |
| CHEMBL5411165 | — | — | 1 | 5.17 |
| CHEMBL5432877 | — | — | 1 | 5.16 |
| CHEMBL5417284 | — | — | 1 | 5.15 |
| CHEMBL5433301 | — | — | 1 | 5.14 |
| CHEMBL5409489 | — | — | 1 | 5.07 |
| CHEMBL5415857 | — | — | 1 | 5.06 |
| CHEMBL5195797 | — | — | 1 | 4.77 |
| CHEMBL5409317 | — | — | 1 | 4.76 |
| CHEMBL5431899 | — | — | 1 | 4.73 |
| CHEMBL5435008 | — | — | 1 | 4.67 |
| CHEMBL5397416 | — | — | 1 | 4.62 |
| CHEMBL5415154 | — | — | 1 | 4.53 |
| CHEMBL5203131 | — | — | 1 | - |
| CHEMBL397237 | — | — | 1 | - |
| CHEMBL5435104 | — | — | 1 | - |
| CHEMBL5426026 | — | — | 1 | - |
| CHEMBL5186932 | — | — | 1 | - |
| CHEMBL5171358 | — | — | 1 | - |
| CHEMBL5203743 | — | — | 1 | - |
| CHEMBL5182926 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5440411 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5434552 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5427907 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5394402 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL5407300 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5173775 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL216981 | NAVARIXIN ANHYDROUS | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL5409816 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL5405321 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL5411713 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL5411165 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL5432877 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL5417284 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL5433301 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5409489 | — | IC50 | = | 8490.0 | nM | 5.07 |
| CHEMBL5415857 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL5195797 | — | IC50 | = | 16920.0 | nM | 4.77 |
| CHEMBL5409317 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL5431899 | — | IC50 | = | 18630.0 | nM | 4.73 |
| CHEMBL5435008 | — | IC50 | = | 21430.0 | nM | 4.67 |
| CHEMBL5397416 | — | IC50 | = | 23780.0 | nM | 4.62 |
| CHEMBL5415154 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL5432227 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5441001 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5432613 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5410642 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5437555 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5184465 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5394281 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5412948 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5394443 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5414164 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5397756 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5425847 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5419389 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5425452 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5396369 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5199496 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5179622 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5179345 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5183117 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5404366 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5182926 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5203743 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5171358 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5186932 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5426026 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5435104 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL397237 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5203131 | — | IC50 | > | 30000.0 | nM | - |