Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5349835

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani promastigotes assessed as parasitic growth inhibition incubated for 3 days by resazurin dye based assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Design, synthesis, and repurposing of O<sup>6</sup>-aminoalkyl-sulfuretin analogs towards discovery of potential lead compounds as antileishmanial agents.
Hassan AHE, Phan TN, Moon S, Lee CH, Kim YJ, Cho SB, El-Sayed SM, Choi Y, No JH, Lee YS.
Eur J Med Chem (2023) 251 : 115256 -115256
PubMed 36944273 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.32 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3359473 1 5.60
CHEMBL3359496 1 5.58
CHEMBL3359493 1 5.55
CHEMBL3359495 1 5.54
CHEMBL3359484 1 5.51
CHEMBL3359492 1 5.51
CHEMBL3359491 1 5.43
CHEMBL28509 EDELFOSINE 2.0 1 5.41
CHEMBL3359480 1 5.39
CHEMBL3359486 1 5.39
CHEMBL3359472 1 5.37
CHEMBL5406282 1 5.34
CHEMBL3359477 1 5.32
CHEMBL3359476 1 5.32
CHEMBL5425245 1 5.28
CHEMBL3359489 1 5.27
CHEMBL5422382 1 5.07
CHEMBL1807493 1 4.58
CHEMBL5427941 1 4.57
CHEMBL3359475 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3359473 IC50 = 2500.0 nM 5.60
CHEMBL3359496 IC50 = 2600.0 nM 5.58
CHEMBL3359493 IC50 = 2800.0 nM 5.55
CHEMBL3359495 IC50 = 2900.0 nM 5.54
CHEMBL3359484 IC50 = 3100.0 nM 5.51
CHEMBL3359492 IC50 = 3100.0 nM 5.51
CHEMBL3359491 IC50 = 3700.0 nM 5.43
CHEMBL28509 EDELFOSINE IC50 = 3900.0 nM 5.41
CHEMBL3359480 IC50 = 4100.0 nM 5.39
CHEMBL3359486 IC50 = 4100.0 nM 5.39
CHEMBL3359472 IC50 = 4300.0 nM 5.37
CHEMBL5406282 IC50 = 4600.0 nM 5.34
CHEMBL3359477 IC50 = 4800.0 nM 5.32
CHEMBL3359476 IC50 = 4800.0 nM 5.32
CHEMBL5425245 IC50 = 5300.0 nM 5.28
CHEMBL3359489 IC50 = 5400.0 nM 5.27
CHEMBL5422382 IC50 = 8600.0 nM 5.07
CHEMBL1807493 IC50 = 26400.0 nM 4.58
CHEMBL5427941 IC50 = 27000.0 nM 4.57
CHEMBL3359475 IC50 > 100000.0 nM -