Assay Detail

CHEMBL5350085

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of human Glutaminase

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Targeting glutaminase 1 (GLS1) by small molecules for anticancer therapeutics.

Chen Y, Tan L, Gao J, Lin C, Wu F, Li Y, Zhang J.
Eur J Med Chem (2023) 252 : 115306 -115306
PubMed 36996714 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	7.26	8.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL51085	EBSELEN	3.0	1	8.05
CHEMBL258893	CHELERYTHRINE CHLORIDE	—	1	7.52
CHEMBL53	APOMORPHINE	4.0	1	6.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL51085	EBSELEN	IC50	=	9.0	nM	8.05
CHEMBL258893	CHELERYTHRINE CHLORIDE	IC50	=	30.0	nM	7.52
CHEMBL53	APOMORPHINE	IC50	=	600.0	nM	6.22