Assay Detail
Binding
CHEMBL5350190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR2 (unknown origin) incubated for 10 mins followed by substrate addition measured after 60 mins by ADP-Glo luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structural Optimization of Novel Quinolone Derivatives as Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.25 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5439595 | — | — | 1 | 8.51 |
| CHEMBL5436527 | — | — | 1 | 8.28 |
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5439595 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5436527 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1289601 | LENVATINIB | IC50 | = | 11.0 | nM | 7.96 |