Assay Detail
Binding
CHEMBL5350631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human VEGF (13 to 107 residues) expressed in Escherichia coli Rosetta (DE3) cells assessed as dissociation constant at 20 degreeC by isothermal titration calorimetry analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor A, long form (CHEMBL1783) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dimer Peptide Ligands of Vascular Endothelial Growth Factor: Optimizing Linker Length for High Affinity and Antiangiogenic Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.67 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325795 | S-ROLIPRAM | — | 1 | 9.18 |
| CHEMBL5433780 | — | — | 1 | 8.05 |
| CHEMBL5395101 | — | — | 1 | 7.82 |
| CHEMBL5408346 | — | — | 1 | 7.75 |
| CHEMBL5424915 | — | — | 1 | 7.70 |
| CHEMBL5417216 | — | — | 1 | 7.66 |
| CHEMBL5413454 | — | — | 1 | 7.58 |
| CHEMBL5438288 | — | — | 1 | 7.30 |
| CHEMBL5429990 | — | — | 1 | 6.89 |
| CHEMBL5439430 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325795 | S-ROLIPRAM | Kd | = | 0.66 | nM | 9.18 |
| CHEMBL5433780 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL5395101 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL5408346 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL5424915 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL5417216 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL5413454 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL5438288 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL5429990 | — | Kd | = | 129.0 | nM | 6.89 |
| CHEMBL5439430 | — | Kd | = | 158.0 | nM | 6.80 |