Assay Detail
Binding
CHEMBL5350866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AKR1C2 (unknown origin) dehydrogenase activity by measuring NADH formation by spectrophotometry
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C2 (CHEMBL5847) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.72 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5427873 | — | — | 1 | 5.32 |
| CHEMBL5402839 | — | — | 1 | 5.29 |
| CHEMBL5401567 | — | — | 1 | 5.22 |
| CHEMBL5412832 | — | — | 1 | 4.96 |
| CHEMBL5408308 | — | — | 1 | 4.92 |
| CHEMBL5401206 | — | — | 1 | 4.90 |
| CHEMBL5440460 | — | — | 1 | 4.85 |
| CHEMBL5409918 | — | — | 1 | 4.82 |
| CHEMBL5409789 | — | — | 1 | 4.80 |
| CHEMBL5407493 | — | — | 1 | 4.80 |
| CHEMBL5412889 | — | — | 1 | 4.70 |
| CHEMBL5411768 | — | — | 1 | 4.66 |
| CHEMBL5402185 | — | — | 1 | 4.60 |
| CHEMBL5432550 | — | — | 1 | 4.54 |
| CHEMBL5422271 | — | — | 1 | 4.51 |
| CHEMBL5408158 | — | — | 1 | 4.44 |
| CHEMBL5437220 | — | — | 1 | 4.44 |
| CHEMBL5441078 | — | — | 1 | 4.43 |
| CHEMBL5403375 | — | — | 1 | 4.41 |
| CHEMBL5417484 | — | — | 1 | 4.32 |
| CHEMBL5436074 | — | — | 1 | 4.21 |
| CHEMBL5424035 | — | — | 1 | - |
| CHEMBL5406207 | — | — | 1 | - |
| CHEMBL4467986 | — | — | 1 | - |
| CHEMBL5435345 | — | — | 1 | - |
| CHEMBL5438117 | — | — | 1 | - |
| CHEMBL5421383 | — | — | 1 | - |
| CHEMBL5427049 | — | — | 1 | - |
| CHEMBL5411601 | — | — | 1 | - |
| CHEMBL5403238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5427873 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5402839 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5401567 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5412832 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5408308 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5401206 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL5440460 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5409918 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5409789 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5407493 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5412889 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5411768 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5402185 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5432550 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5422271 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL5437220 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL5408158 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL5441078 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5403375 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL5417484 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL5436074 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL5411357 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5405662 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5397612 | — | IC50 | - | — | - | |
| CHEMBL5403238 | — | IC50 | - | — | - | |
| CHEMBL5411601 | — | IC50 | - | — | - | |
| CHEMBL5427049 | — | IC50 | - | — | - | |
| CHEMBL5421383 | — | IC50 | - | — | - | |
| CHEMBL5438117 | — | IC50 | - | — | - | |
| CHEMBL5435345 | — | IC50 | - | — | - | |
| CHEMBL4467986 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL5406207 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5424035 | — | IC50 | = | 156000.0 | nM | - |