Assay Detail
Binding
CHEMBL5350895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ACE2 (18 to 740 residues) using Mca-APK(Dnp) as substrate incubated for 15 mins followed by substrate addition by fluorescence based analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Guided Chemical Optimization of Bicyclic Peptide (<i>Bicycle</i>) Inhibitors of Angiotensin-Converting Enzyme 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.93 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5430631 | — | — | 1 | 9.31 |
| CHEMBL5406655 | — | — | 1 | 9.19 |
| CHEMBL5394399 | — | — | 1 | 9.19 |
| CHEMBL5424883 | — | — | 1 | 9.11 |
| CHEMBL5395954 | — | — | 1 | 8.70 |
| CHEMBL5403774 | — | — | 1 | 8.59 |
| CHEMBL5429094 | — | — | 1 | 8.57 |
| CHEMBL5415414 | — | — | 1 | 8.49 |
| CHEMBL5424641 | — | — | 1 | 8.48 |
| CHEMBL5429562 | — | — | 1 | 8.35 |
| CHEMBL5396932 | — | — | 1 | 8.31 |
| CHEMBL5433480 | — | — | 1 | 8.15 |
| CHEMBL5434946 | — | — | 1 | 8.00 |
| CHEMBL5400018 | — | — | 1 | 7.96 |
| CHEMBL5397691 | — | — | 1 | 7.92 |
| CHEMBL5420290 | — | — | 1 | 7.89 |
| CHEMBL5437403 | — | — | 1 | 7.77 |
| CHEMBL5429801 | — | — | 1 | 7.41 |
| CHEMBL5415513 | — | — | 1 | 7.33 |
| CHEMBL5400083 | — | — | 1 | 7.21 |
| CHEMBL5402703 | — | — | 1 | 7.01 |
| CHEMBL5410380 | — | — | 1 | 6.92 |
| CHEMBL5434641 | — | — | 1 | 5.62 |
| CHEMBL5420202 | — | — | 1 | 4.92 |
| CHEMBL5407252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5430631 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5406655 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL5394399 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL5424883 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL5395954 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5403774 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5429094 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5415414 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5424641 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5429562 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5396932 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5433480 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5434946 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5400018 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5397691 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5420290 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5437403 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5429801 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5415513 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5400083 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5402703 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5410380 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5434641 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5420202 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5407252 | — | IC50 | > | 40000.0 | nM | - |