Assay Detail
Functional
CHEMBL5351364
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Inhibition of pre-miR-21 (unknown origin) dicer cleavage activity preincubated for 30 mins followed by RNAase III addition and measured after 30 to 60 mins by FRET method
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of Bleomycin-Inspired RNA Ligands Targeting the Biogenesis of Oncogenic miRNAs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.82 | 5.79 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422790 | — | — | 1 | 5.79 |
| CHEMBL5413573 | — | — | 1 | 5.43 |
| CHEMBL5417854 | — | — | 1 | 4.93 |
| CHEMBL5405932 | — | — | 1 | 4.79 |
| CHEMBL5406620 | — | — | 1 | 4.69 |
| CHEMBL5424223 | — | — | 1 | 4.69 |
| CHEMBL5393793 | — | — | 1 | 4.51 |
| CHEMBL5406161 | — | — | 1 | 4.42 |
| CHEMBL5438709 | — | — | 1 | 4.12 |
| CHEMBL5428791 | — | — | 1 | - |
| CHEMBL5428849 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422790 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL5413573 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL5417854 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL5405932 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL5406620 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL5424223 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL5393793 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL5406161 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL5438709 | — | IC50 | = | 75900.0 | nM | 4.12 |
| CHEMBL5428791 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL5428849 | — | Inhibition | - | % | - |