Assay Detail
Functional
CHEMBL5351479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.56 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422297 | — | — | 1 | 8.00 |
| CHEMBL5415644 | — | — | 1 | 7.92 |
| CHEMBL5423275 | — | — | 1 | 7.38 |
| CHEMBL5411053 | — | — | 1 | 7.12 |
| CHEMBL5421974 | — | — | 1 | 7.06 |
| CHEMBL5395488 | — | — | 1 | 7.02 |
| CHEMBL5398334 | — | — | 1 | 7.00 |
| CHEMBL1499544 | — | — | 1 | 6.92 |
| CHEMBL4747331 | — | — | 1 | 6.85 |
| CHEMBL5430901 | — | — | 1 | 6.82 |
| CHEMBL5421524 | — | — | 1 | 6.75 |
| CHEMBL5429773 | — | — | 1 | 6.72 |
| CHEMBL5403051 | — | — | 1 | 6.70 |
| CHEMBL5420667 | — | — | 1 | 6.64 |
| CHEMBL5419173 | — | — | 1 | 6.55 |
| CHEMBL5418810 | — | — | 1 | 6.52 |
| CHEMBL5440368 | — | — | 1 | 6.43 |
| CHEMBL5422330 | — | — | 1 | 6.42 |
| CHEMBL5407576 | — | — | 1 | 6.42 |
| CHEMBL5415851 | — | — | 1 | 6.29 |
| CHEMBL5409038 | — | — | 1 | 6.29 |
| CHEMBL5417015 | — | — | 1 | 6.29 |
| CHEMBL5426256 | — | — | 1 | 6.29 |
| CHEMBL5413967 | — | — | 1 | 6.27 |
| CHEMBL5425843 | — | — | 1 | 6.25 |
| CHEMBL5430321 | — | — | 1 | 6.24 |
| CHEMBL5401512 | — | — | 1 | 6.19 |
| CHEMBL5400972 | — | — | 1 | 6.17 |
| CHEMBL5403308 | — | — | 1 | 6.07 |
| CHEMBL5432797 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422297 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5415644 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5423275 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5411053 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5421974 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5395488 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5398334 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1499544 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4747331 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5430901 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5421524 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5429773 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5403051 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5420667 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5419173 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5418810 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5440368 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5422330 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5407576 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5415851 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5409038 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5417015 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5426256 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5413967 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5425843 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5430321 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5401512 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5400972 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5403308 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5432797 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5398067 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5439613 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5393889 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5396024 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5407128 | — | IC50 | = | 1130.0 | nM | 5.95 |