Assay Detail
Binding
CHEMBL5351528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GPX4 (unknown origin) incubated for 1 hrs in presence of glutathione and glutathione reductase by microplate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospholipid hydroperoxide glutathione peroxidase GPX4 (CHEMBL4295754) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.05 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422297 | — | — | 1 | 6.92 |
| CHEMBL5415644 | — | — | 1 | 6.89 |
| CHEMBL1499544 | — | — | 1 | 5.31 |
| CHEMBL4747331 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422297 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5415644 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1499544 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL4747331 | — | IC50 | = | 8420.0 | nM | 5.08 |