Assay Detail
Binding
CHEMBL5351772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat alpha7 nACh receptor expressed in Xenopus oocyte assessed as inhibition of acetylcholine-induced response at -70 mV holding potential by voltage-clamp based electrophysiological assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-Activity Relationships of Alanine Scan Mutants αO-Conotoxins GeXIVA[1,2] and GeXIVA[1,4].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 5.56 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5427617 | — | — | 1 | 6.22 |
| CHEMBL4460879 | — | — | 1 | 6.19 |
| CHEMBL5436170 | — | — | 1 | 6.19 |
| CHEMBL5396121 | — | — | 1 | 6.19 |
| CHEMBL5407174 | — | — | 1 | 6.12 |
| CHEMBL5439154 | — | — | 1 | 5.97 |
| CHEMBL5426596 | — | — | 1 | 5.95 |
| CHEMBL5409922 | — | — | 1 | 5.87 |
| CHEMBL5403043 | — | — | 1 | 5.85 |
| CHEMBL5419863 | — | — | 1 | 5.84 |
| CHEMBL5428141 | — | — | 1 | 5.84 |
| CHEMBL5426847 | — | — | 1 | 5.83 |
| CHEMBL5398766 | — | — | 1 | 5.80 |
| CHEMBL5404672 | — | — | 1 | 5.77 |
| CHEMBL5432748 | — | — | 1 | 5.75 |
| CHEMBL5435010 | — | — | 1 | 5.72 |
| CHEMBL5406714 | — | — | 1 | 5.69 |
| CHEMBL5426358 | — | — | 1 | 5.65 |
| CHEMBL5401197 | — | — | 1 | 5.61 |
| CHEMBL4553407 | — | — | 1 | 5.55 |
| CHEMBL5394070 | — | — | 1 | 5.52 |
| CHEMBL5440747 | — | — | 1 | 5.51 |
| CHEMBL5396129 | — | — | 1 | 5.48 |
| CHEMBL5413221 | — | — | 1 | 5.42 |
| CHEMBL5422303 | — | — | 1 | 5.39 |
| CHEMBL5396311 | — | — | 1 | 5.35 |
| CHEMBL5428546 | — | — | 1 | 5.34 |
| CHEMBL5435613 | — | — | 1 | 5.33 |
| CHEMBL5432265 | — | — | 1 | 5.33 |
| CHEMBL5423851 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5427617 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4460879 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5396121 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5436170 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5407174 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5439154 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5426596 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5409922 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5403043 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL5419863 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5428141 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5426847 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5398766 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5404672 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5432748 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL5435010 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5406714 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5426358 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL5401197 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4553407 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL5394070 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL5440747 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL5396129 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL5413221 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL5422303 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5396311 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL5428546 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL5435613 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL5432265 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL5423851 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL5413345 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5419995 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL5416147 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL5393774 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL5400807 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL5394317 | — | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL5427601 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL5431759 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL5394483 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL5420643 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL5417971 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL5425181 | — | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL5414842 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5440425 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5423816 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5420679 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5422661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5432876 | — | IC50 | > | 10000.0 | nM | - |