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Assay Detail

CHEMBL5352589

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MIA PaCa-2
Confidence 1 — Organism
Curated By Autocuration

Target

MIA PaCa-2 (CHEMBL614725)
Type CELL-LINE
Organism Homo sapiens

Publication

Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer.
Bai JF, Majjigapu SR, Sordat B, Poty S, Vogel P, Elías-Rodríguez P, Moreno-Vargas AJ, Carmona AT, Caffa I, Ghanem M, Khalifa A, Monacelli F, Cea M, Robina I, Gajate C, Mollinedo F, Bellotti A, Nahimana A, Duchosal M, Nencioni A.
Eur J Med Chem (2022) 239 : 114504 -114504
PubMed 35724566 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 8.41 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5401413 1 9.80
CHEMBL5410343 1 9.60
CHEMBL5411332 1 9.30
CHEMBL5396938 1 9.10
CHEMBL5411308 1 9.00
CHEMBL566757 DAPORINAD 2.0 1 8.66
CHEMBL5399830 1 8.57
CHEMBL5430148 1 8.52
CHEMBL5420600 1 8.41
CHEMBL5408569 1 8.41
CHEMBL5435400 1 8.40
CHEMBL5414612 1 8.40
CHEMBL5403829 1 8.35
CHEMBL5431996 1 7.89
CHEMBL5425840 1 7.87
CHEMBL5431482 1 7.62
CHEMBL5399381 1 7.60
CHEMBL5394594 1 7.16
CHEMBL5409112 1 7.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5401413 IC50 = 0.16 nM 9.80
CHEMBL5410343 IC50 = 0.25 nM 9.60
CHEMBL5411332 IC50 = 0.5 nM 9.30
CHEMBL5396938 IC50 = 0.8 nM 9.10
CHEMBL5411308 IC50 = 1.0 nM 9.00
CHEMBL566757 DAPORINAD IC50 = 2.2 nM 8.66
CHEMBL5399830 IC50 = 2.7 nM 8.57
CHEMBL5430148 IC50 = 3.0 nM 8.52
CHEMBL5420600 IC50 = 3.9 nM 8.41
CHEMBL5408569 IC50 = 3.9 nM 8.41
CHEMBL5435400 IC50 = 4.0 nM 8.40
CHEMBL5414612 IC50 = 4.0 nM 8.40
CHEMBL5403829 IC50 = 4.5 nM 8.35
CHEMBL5431996 IC50 = 13.0 nM 7.89
CHEMBL5425840 IC50 = 13.5 nM 7.87
CHEMBL5431482 IC50 = 24.0 nM 7.62
CHEMBL5399381 IC50 = 25.0 nM 7.60
CHEMBL5394594 IC50 = 69.0 nM 7.16
CHEMBL5409112 IC50 = 75.0 nM 7.12