Assay Detail
Functional
CHEMBL5352770
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of novel indole derivatives as highly potent and efficacious LSD1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.38 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399676 | — | — | 1 | 6.13 |
| CHEMBL5437172 | — | — | 1 | 5.64 |
| CHEMBL5422540 | — | — | 1 | 5.64 |
| CHEMBL5397056 | — | — | 1 | 5.57 |
| CHEMBL5423110 | — | — | 1 | 5.47 |
| CHEMBL5399692 | — | — | 1 | 5.46 |
| CHEMBL4863608 | — | — | 1 | 5.44 |
| CHEMBL5435872 | — | — | 1 | 5.38 |
| CHEMBL5434343 | — | — | 1 | 5.37 |
| CHEMBL5428732 | — | — | 1 | 5.28 |
| CHEMBL5428936 | — | — | 1 | 5.26 |
| CHEMBL5404090 | — | — | 1 | 5.06 |
| CHEMBL5437435 | — | — | 1 | 4.81 |
| CHEMBL5410672 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399676 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5437172 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5422540 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5397056 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5423110 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5399692 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4863608 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5435872 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5434343 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5428732 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5428936 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5404090 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5437435 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5410672 | — | IC50 | = | 17300.0 | nM | 4.76 |