Assay Detail
Functional
CHEMBL5352774
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Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of novel indole derivatives as highly potent and efficacious LSD1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.00 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423110 | — | — | 1 | 5.34 |
| CHEMBL5428936 | — | — | 1 | 5.28 |
| CHEMBL5399676 | — | — | 1 | 5.24 |
| CHEMBL5428732 | — | — | 1 | 5.06 |
| CHEMBL5404090 | — | — | 1 | 5.05 |
| CHEMBL5435872 | — | — | 1 | 5.03 |
| CHEMBL5437435 | — | — | 1 | 5.01 |
| CHEMBL5437172 | — | — | 1 | 5.01 |
| CHEMBL4863608 | — | — | 1 | 4.94 |
| CHEMBL5397056 | — | — | 1 | 4.92 |
| CHEMBL5410672 | — | — | 1 | 4.89 |
| CHEMBL5434343 | — | — | 1 | 4.81 |
| CHEMBL5399692 | — | — | 1 | 4.81 |
| CHEMBL5422540 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423110 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5428936 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5399676 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5428732 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5404090 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5435872 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5437435 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5437172 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4863608 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL5397056 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL5410672 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL5434343 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5399692 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5422540 | — | IC50 | = | 24000.0 | nM | 4.62 |