Assay Detail
Binding
CHEMBL5352829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MAO-A using p-tyramine as substrate incubated for 15 mins by Amplex red and horseradish peroxidase based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.82 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.16 |
| CHEMBL5410794 | — | — | 1 | 6.22 |
| CHEMBL5417198 | — | — | 1 | 5.47 |
| CHEMBL5421246 | — | — | 1 | 5.21 |
| CHEMBL5400189 | — | — | 1 | 5.05 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 68.7 | nM | 7.16 |
| CHEMBL5410794 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL5417198 | — | IC50 | = | 3374.0 | nM | 5.47 |
| CHEMBL5421246 | — | IC50 | = | 6186.0 | nM | 5.21 |
| CHEMBL5400189 | — | IC50 | = | 8996.0 | nM | 5.05 |
| CHEMBL887 | RASAGILINE | IC50 | = | 53.0 | nM | - |
| CHEMBL8706 | CLORGILINE | IC50 | = | 0.004 | nM | - |