Assay Detail
Binding
CHEMBL5352830
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Inhibition of human MAO-B using p-tyramine as substrate incubated for 15 mins by Amplex red and horseradish peroxidase based fluorescence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.32 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 10.77 |
| CHEMBL4074532 | — | — | 1 | 8.17 |
| CHEMBL5437543 | — | — | 1 | 8.08 |
| CHEMBL4078090 | — | — | 1 | 7.99 |
| CHEMBL5403995 | — | — | 1 | 7.89 |
| CHEMBL5429656 | — | — | 1 | 7.84 |
| CHEMBL5431945 | — | — | 1 | 7.81 |
| CHEMBL5416761 | — | — | 1 | 7.80 |
| CHEMBL5431507 | — | — | 1 | 7.60 |
| CHEMBL5422519 | — | — | 1 | 7.55 |
| CHEMBL5417198 | — | — | 1 | 7.54 |
| CHEMBL5404200 | — | — | 1 | 7.53 |
| CHEMBL5406057 | — | — | 1 | 7.50 |
| CHEMBL4070614 | — | — | 1 | 7.38 |
| CHEMBL5423045 | — | — | 1 | 7.26 |
| CHEMBL5400189 | — | — | 1 | 7.16 |
| CHEMBL5421246 | — | — | 1 | 7.01 |
| CHEMBL4075920 | — | — | 1 | 6.68 |
| CHEMBL5432117 | — | — | 1 | 6.62 |
| CHEMBL5415156 | — | — | 1 | 6.58 |
| CHEMBL5425546 | — | — | 1 | 6.46 |
| CHEMBL5426795 | — | — | 1 | 6.22 |
| CHEMBL4102366 | — | — | 1 | 6.17 |
| CHEMBL5423398 | — | — | 1 | 5.99 |
| CHEMBL5423186 | — | — | 1 | 5.32 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 0.017 | nM | 10.77 |
| CHEMBL4074532 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5437543 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4078090 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL5403995 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5429656 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL5431945 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL5416761 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL5431507 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5422519 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL5417198 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL5404200 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL5406057 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL4070614 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL5423045 | — | IC50 | = | 55.1 | nM | 7.26 |
| CHEMBL5400189 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL5421246 | — | IC50 | = | 97.2 | nM | 7.01 |
| CHEMBL4075920 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL5432117 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5415156 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL5425546 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL5426795 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL4102366 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL5423398 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5423186 | — | IC50 | = | 4829.0 | nM | 5.32 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 63.4 | nM | - |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 0.023 | nM | - |
| CHEMBL887 | RASAGILINE | IC50 | = | 0.05 | nM | - |