Assay Detail
Binding
CHEMBL5352937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Hsp90 (unknown origin) by TR-FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.75 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5396806 | — | — | 1 | 7.16 |
| CHEMBL5439362 | — | — | 1 | 6.90 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.87 |
| CHEMBL5396795 | — | — | 1 | 6.83 |
| CHEMBL5406770 | — | — | 1 | 6.44 |
| CHEMBL5407152 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5396806 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5439362 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5396795 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL5406770 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL5407152 | — | IC50 | = | 476.0 | nM | 6.32 |