Assay Detail
Binding
CHEMBL5352938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin) by kinase profiling assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.27 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 8.22 |
| CHEMBL5396806 | — | — | 1 | 7.54 |
| CHEMBL5407152 | — | — | 1 | 7.14 |
| CHEMBL5396795 | — | — | 1 | 7.09 |
| CHEMBL5406770 | — | — | 1 | 6.97 |
| CHEMBL5439362 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5396806 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5407152 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5396795 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5406770 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL5439362 | — | IC50 | = | 218.0 | nM | 6.66 |