Assay Detail
Functional
CHEMBL5352941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human T24 cells assessed as inhibition of cell proliferation by CCK8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-24 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.97 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5396806 | — | — | 1 | 6.39 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.27 |
| CHEMBL5406770 | — | — | 1 | 6.26 |
| CHEMBL5439362 | — | — | 1 | 6.03 |
| CHEMBL5407152 | — | — | 1 | 5.78 |
| CHEMBL5396795 | — | — | 1 | 5.76 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5396806 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5406770 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5439362 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5407152 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL5396795 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 4930.0 | nM | 5.31 |