Assay Detail
Functional
CHEMBL5353012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human GCT cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GCT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.09 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419419 | — | — | 1 | 7.48 |
| CHEMBL5402907 | — | — | 1 | 7.31 |
| CHEMBL5435465 | — | — | 1 | 7.24 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.86 |
| CHEMBL5411383 | — | — | 1 | 6.72 |
| CHEMBL5430629 | — | — | 1 | 6.50 |
| CHEMBL5426184 | — | — | 1 | 6.40 |
| CHEMBL5398696 | — | — | 1 | 6.30 |
| CHEMBL5424746 | — | — | 1 | 6.18 |
| CHEMBL5404458 | — | — | 1 | 6.18 |
| CHEMBL5431727 | — | — | 1 | 6.15 |
| CHEMBL5437189 | — | — | 1 | 6.12 |
| CHEMBL5418202 | — | — | 1 | 6.00 |
| CHEMBL5398210 | — | — | 1 | 5.97 |
| CHEMBL5419526 | — | — | 1 | 5.89 |
| CHEMBL5418784 | — | — | 1 | 5.77 |
| CHEMBL5435494 | — | — | 1 | 5.53 |
| CHEMBL5404969 | — | — | 1 | 5.45 |
| CHEMBL5438166 | — | — | 1 | 5.43 |
| CHEMBL5415855 | — | — | 1 | 5.39 |
| CHEMBL5419426 | — | — | 1 | 5.19 |
| CHEMBL5433876 | — | — | 1 | 5.05 |
| CHEMBL5427412 | — | — | 1 | 4.97 |
| CHEMBL5432708 | — | — | 1 | - |
| CHEMBL5409200 | — | — | 1 | - |
| CHEMBL5438641 | — | — | 1 | - |
| CHEMBL5427608 | — | — | 1 | - |
| CHEMBL5403039 | — | — | 1 | - |
| CHEMBL5397754 | — | — | 1 | - |
| CHEMBL5413448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419419 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5402907 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5435465 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL5411383 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL5430629 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL5426184 | — | IC50 | = | 402.0 | nM | 6.40 |
| CHEMBL5398696 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL5424746 | — | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL5404458 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL5431727 | — | IC50 | = | 711.0 | nM | 6.15 |
| CHEMBL5437189 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL5418202 | — | IC50 | = | 1001.0 | nM | 6.00 |
| CHEMBL5398210 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL5419526 | — | IC50 | = | 1274.0 | nM | 5.89 |
| CHEMBL5418784 | — | IC50 | = | 1686.0 | nM | 5.77 |
| CHEMBL5435494 | — | IC50 | = | 2927.0 | nM | 5.53 |
| CHEMBL5404969 | — | IC50 | = | 3551.0 | nM | 5.45 |
| CHEMBL5438166 | — | IC50 | = | 3719.0 | nM | 5.43 |
| CHEMBL5415855 | — | IC50 | = | 4034.0 | nM | 5.39 |
| CHEMBL5419426 | — | IC50 | = | 6493.0 | nM | 5.19 |
| CHEMBL5433876 | — | IC50 | = | 8862.0 | nM | 5.05 |
| CHEMBL5427412 | — | IC50 | = | 10750.0 | nM | 4.97 |
| CHEMBL5395212 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5403452 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5410859 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5418136 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5414117 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5395456 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5396787 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5413448 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5397754 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5403039 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5427608 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5438641 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5409200 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5432708 | — | IC50 | > | 20000.0 | nM | - |