Assay Detail
Functional
CHEMBL5353204
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Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel non-nucleoside inhibitors with high potency and selectivity for DNA methyltransferase 3A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.15 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5425605 | — | — | 1 | 5.68 |
| CHEMBL5414585 | — | — | 1 | 5.34 |
| CHEMBL5428173 | — | — | 1 | 5.07 |
| CHEMBL2336409 | — | — | 1 | 5.05 |
| CHEMBL5415008 | — | — | 1 | 4.96 |
| CHEMBL5404240 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5425605 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5414585 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5428173 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2336409 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5415008 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL5404240 | — | IC50 | = | 15700.0 | nM | 4.80 |