Assay Detail
Binding
CHEMBL5353415
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Inhibition of ZIKV NS5 MTase activity assessed as methyltransferase reaction using capped RNA substrate pre-incubated for 2.5 hrs followed by enzyme addition measured after 1 hrs by luminometer
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zika virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.68 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5421176 | — | — | 1 | 4.85 |
| CHEMBL5402544 | — | — | 1 | 4.74 |
| CHEMBL1214186 | SINEFUNGIN | 2.0 | 1 | 4.72 |
| CHEMBL4206100 | — | — | 1 | 4.41 |
| CHEMBL5414044 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5421176 | — | IC50 | = | 14130.0 | nM | 4.85 |
| CHEMBL5402544 | — | IC50 | = | 18340.0 | nM | 4.74 |
| CHEMBL1214186 | SINEFUNGIN | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4206100 | — | IC50 | = | 38860.0 | nM | 4.41 |
| CHEMBL5414044 | — | IC50 | = | 183250.0 | nM | - |