Assay Detail
Functional
CHEMBL5353547
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Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by CCK8 assay
45
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1,2-diphenylethene derivatives as human DNA topoisomerase II catalytic inhibitors and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.92 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399261 | — | — | 1 | 6.70 |
| CHEMBL5424300 | — | — | 1 | 6.10 |
| CHEMBL5418790 | — | — | 2 | 5.44 |
| CHEMBL5419187 | — | — | 1 | 5.42 |
| CHEMBL5403919 | — | — | 1 | 5.38 |
| CHEMBL3329222 | — | — | 1 | 5.37 |
| CHEMBL5399988 | — | — | 1 | 5.34 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.25 |
| CHEMBL5409654 | — | — | 1 | 5.24 |
| CHEMBL5430291 | — | — | 1 | 5.14 |
| CHEMBL5413747 | — | — | 1 | 5.14 |
| CHEMBL5423037 | — | — | 1 | 5.11 |
| CHEMBL5404654 | — | — | 1 | 5.11 |
| CHEMBL5406242 | — | — | 1 | 5.02 |
| CHEMBL5437018 | — | — | 1 | 4.98 |
| CHEMBL5438701 | — | — | 1 | 4.95 |
| CHEMBL5408248 | — | — | 1 | 4.94 |
| CHEMBL5436055 | — | — | 1 | 4.92 |
| CHEMBL5415871 | — | — | 1 | 4.92 |
| CHEMBL5415636 | — | — | 1 | 4.90 |
| CHEMBL5410845 | — | — | 1 | 4.87 |
| CHEMBL5440044 | — | — | 1 | 4.81 |
| CHEMBL5413876 | — | — | 1 | 4.80 |
| CHEMBL5398321 | — | — | 1 | 4.78 |
| CHEMBL5403221 | — | — | 1 | 4.78 |
| CHEMBL5403522 | — | — | 1 | 4.72 |
| CHEMBL5421402 | — | — | 1 | 4.70 |
| CHEMBL5430260 | — | — | 1 | 4.70 |
| CHEMBL5418959 | — | — | 1 | 4.70 |
| CHEMBL5401304 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399261 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5424300 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5418790 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5419187 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5418790 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5403919 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3329222 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5399988 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5409654 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5430291 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5413747 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5423037 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5404654 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5406242 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5437018 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5438701 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5408248 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL5415871 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL5436055 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5415636 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL5410845 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL5440044 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5413876 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL5398321 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5403221 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5403522 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL5430260 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL5421402 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL5418959 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL5413594 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL5401304 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL5403378 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL5435393 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL5412740 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL5432112 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL5425612 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL5412968 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL5398839 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL5411959 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL92390 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL5417329 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL5396104 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL5395090 | — | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL5410440 | — | IC50 | = | 42300.0 | nM | 4.37 |