Assay Detail
Binding
CHEMBL5353628
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Binding affinity to human dopamine D3 receptor expressed in CHO cells assessed as inhibition constant
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D<sub>2</sub> receptors for treatment of somatic and visceral pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.60 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1423 | PIMOZIDE | 4.0 | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1423 | PIMOZIDE | Ki | = | 2.5 | nM | 8.60 |