Assay Detail
Binding
CHEMBL5354101
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Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.13 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.64 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.41 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 6.83 |
| CHEMBL5095023 | LS-104 | 1.0 | 1 | 5.94 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.66 |
| CHEMBL2018554 | — | — | 1 | 5.60 |
| CHEMBL5410682 | — | — | 1 | 5.37 |
| CHEMBL5400279 | — | — | 1 | 5.36 |
| CHEMBL5421285 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL972 | SELEGILINE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL887 | RASAGILINE | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL5095023 | LS-104 | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL2018554 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5410682 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL5400279 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL5421285 | — | IC50 | = | 4550.0 | nM | 5.34 |