Assay Detail
Functional
CHEMBL5354479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 4.82 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5424343 | — | — | 1 | 5.85 |
| CHEMBL5400431 | — | — | 1 | 5.80 |
| CHEMBL5398904 | — | — | 1 | 5.80 |
| CHEMBL5428024 | — | — | 1 | 5.77 |
| CHEMBL5427668 | — | — | 1 | 5.57 |
| CHEMBL5430299 | — | — | 1 | 5.09 |
| CHEMBL5403142 | — | — | 1 | 4.72 |
| CHEMBL5395805 | — | — | 1 | 4.70 |
| CHEMBL5404022 | — | — | 1 | 4.66 |
| CHEMBL5405364 | — | — | 1 | 4.62 |
| CHEMBL296567 | DIHYDROBETULONIC ACID | — | 1 | 4.57 |
| CHEMBL5427078 | — | — | 1 | 4.54 |
| CHEMBL2179603 | — | — | 1 | 4.51 |
| CHEMBL221890 | — | — | 1 | 4.50 |
| CHEMBL5424352 | — | — | 1 | 4.46 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 4.42 |
| CHEMBL5408390 | — | — | 1 | 4.40 |
| CHEMBL5430486 | — | — | 1 | 4.35 |
| CHEMBL5405828 | — | — | 1 | 4.34 |
| CHEMBL470029 | OLEANONIC ACID | — | 1 | 4.31 |
| CHEMBL5440337 | — | — | 1 | 4.30 |
| CHEMBL5398712 | — | — | 1 | - |
| CHEMBL5425414 | — | — | 1 | - |
| CHEMBL5411390 | — | — | 1 | - |
| CHEMBL5439655 | — | — | 1 | - |
| CHEMBL5423517 | — | — | 1 | - |
| CHEMBL5397295 | — | — | 1 | - |
| CHEMBL5422081 | — | — | 1 | - |
| CHEMBL5428339 | — | — | 1 | - |
| CHEMBL3233721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5424343 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5400431 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5398904 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5428024 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5427668 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5430299 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5403142 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5395805 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5404022 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5405364 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL296567 | DIHYDROBETULONIC ACID | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5427078 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2179603 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL221890 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5424352 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5408390 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5430486 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL5405828 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL5440337 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5434622 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3134501 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5411079 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL562059 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5429967 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL472646 | MORONIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL5436926 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5403576 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL487887 | URSONIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL5393931 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5398712 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3233721 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5428339 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5422081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5397295 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5423517 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5439655 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5411390 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5425414 | — | IC50 | > | 50000.0 | nM | - |