Assay Detail
Binding
CHEMBL5354518
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Agonist activity at human TLR2 expressed in HEK-Blue hTLR2 cells as SEAP expression incubated for 16 hrs by SEAP-based plate reader analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-Blue hTLR2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472879 | — | — | 1 | 7.82 |
| CHEMBL5418054 | — | — | 1 | 7.46 |
| CHEMBL5425244 | — | — | 1 | 7.43 |
| CHEMBL5402655 | — | — | 1 | 7.41 |
| CHEMBL5433647 | — | — | 1 | 7.06 |
| CHEMBL5408351 | — | — | 1 | 6.97 |
| CHEMBL5417613 | — | — | 1 | 6.75 |
| CHEMBL5437599 | — | — | 1 | 6.54 |
| CHEMBL5421254 | — | — | 1 | 6.29 |
| CHEMBL5412350 | — | — | 1 | 6.16 |
| CHEMBL5409558 | — | — | 1 | 6.15 |
| CHEMBL5436471 | — | — | 1 | 5.82 |
| CHEMBL5429560 | — | — | 1 | - |
| CHEMBL5426657 | — | — | 1 | - |
| CHEMBL5425317 | — | — | 1 | - |
| CHEMBL5440667 | — | — | 1 | - |
| CHEMBL5440490 | — | — | 1 | - |
| CHEMBL5436363 | — | — | 1 | - |
| CHEMBL5430289 | — | — | 1 | - |
| CHEMBL5407272 | — | — | 1 | - |
| CHEMBL5406193 | — | — | 1 | - |
| CHEMBL5404208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472879 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5418054 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5425244 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5402655 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5433647 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5408351 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5417613 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5437599 | — | EC50 | = | 286.0 | nM | 6.54 |
| CHEMBL5421254 | — | EC50 | = | 514.0 | nM | 6.29 |
| CHEMBL5412350 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5409558 | — | EC50 | = | 702.0 | nM | 6.15 |
| CHEMBL5436471 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5429560 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5426657 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5425317 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5440667 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5440490 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5436363 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5430289 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5407272 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5406193 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5404208 | — | EC50 | > | 5000.0 | nM | - |