Assay Detail
Binding
CHEMBL5354768
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Agonist activity at STING in PMA-treated human THP-1 reporter cells incubated for 30 mins in presence of digitonin by QUANTI-Luc assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.14 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397460 | — | — | 1 | 8.21 |
| CHEMBL5427569 | — | — | 1 | 7.94 |
| CHEMBL4465054 | — | — | 1 | 7.55 |
| CHEMBL5190773 | — | — | 1 | 6.88 |
| CHEMBL5413946 | — | — | 1 | 6.50 |
| CHEMBL5416367 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397460 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5427569 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL4465054 | — | EC50 | = | 28.3 | nM | 7.55 |
| CHEMBL5190773 | — | EC50 | = | 131.4 | nM | 6.88 |
| CHEMBL5413946 | — | EC50 | = | 316.6 | nM | 6.50 |
| CHEMBL5416367 | — | EC50 | = | 1796.0 | nM | 5.75 |