Assay Detail
Functional
CHEMBL5354969
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Antiproliferative activity against human MINO cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MINO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.51 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3885009 | — | — | 1 | 7.70 |
| CHEMBL3884079 | — | — | 1 | 7.16 |
| CHEMBL4515731 | — | — | 1 | 7.16 |
| CHEMBL4452973 | — | — | 1 | 6.64 |
| CHEMBL4463720 | — | — | 1 | 6.64 |
| CHEMBL4581544 | — | — | 1 | 6.43 |
| CHEMBL5428260 | — | — | 1 | 6.30 |
| CHEMBL5401200 | — | — | 1 | 6.30 |
| CHEMBL3885050 | — | — | 1 | 6.16 |
| CHEMBL4455179 | — | — | 1 | 5.96 |
| CHEMBL5401776 | — | — | 1 | 5.85 |
| CHEMBL5398172 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3885009 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3884079 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4515731 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4452973 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4463720 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4581544 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5428260 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5401200 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3885050 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4455179 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5401776 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5398172 | — | IC50 | = | 1400.0 | nM | 5.85 |