Assay Detail
Binding
CHEMBL5355127
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine trypsin using S-2765 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.14 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266349 | MELAGATRAN | 4.0 | 1 | 7.30 |
| CHEMBL5413299 | — | — | 1 | 6.66 |
| CHEMBL5424963 | — | — | 1 | 6.55 |
| CHEMBL48361 | DABIGATRAN | 3.0 | 1 | 5.91 |
| CHEMBL5427665 | — | — | 1 | 5.29 |
| CHEMBL5423783 | — | — | 1 | 5.08 |
| CHEMBL5425457 | — | — | 1 | 4.88 |
| CHEMBL5397540 | — | — | 1 | 4.83 |
| CHEMBL5429063 | — | — | 1 | 4.76 |
| CHEMBL5435750 | — | — | 1 | 4.59 |
| CHEMBL5425205 | — | — | 1 | 4.48 |
| CHEMBL1575426 | — | — | 1 | 4.30 |
| CHEMBL502016 | — | — | 1 | 4.23 |
| CHEMBL5430930 | — | — | 1 | 4.12 |
| CHEMBL5438252 | — | — | 1 | 4.06 |
| CHEMBL5431421 | — | — | 1 | - |
| CHEMBL5418447 | — | — | 1 | - |
| CHEMBL5430493 | — | — | 1 | - |
| CHEMBL5429800 | — | — | 1 | - |
| CHEMBL1535020 | — | — | 1 | - |
| CHEMBL5440166 | — | — | 1 | - |
| CHEMBL5409763 | — | — | 1 | - |
| CHEMBL5418843 | — | — | 1 | - |
| CHEMBL1444918 | — | — | 1 | - |
| CHEMBL1560937 | — | — | 1 | - |
| CHEMBL5424957 | — | — | 1 | - |
| CHEMBL5426834 | — | — | 1 | - |
| CHEMBL5408843 | — | — | 1 | - |
| CHEMBL5432782 | — | — | 1 | - |
| CHEMBL5402933 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266349 | MELAGATRAN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5413299 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL5424963 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL48361 | DABIGATRAN | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL5427665 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL5423783 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5425457 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5397540 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL5429063 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL5435750 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL5425205 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1575426 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL502016 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL5430930 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL5438252 | — | IC50 | = | 87700.0 | nM | 4.06 |
| CHEMBL5424153 | — | IC50 | - | — | - | |
| CHEMBL5422724 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5395641 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1373768 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5420677 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5418604 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL198362 | RIVAROXABAN | IC50 | > | 100000.0 | nM | - |
| CHEMBL5431421 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5418447 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5430493 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5429800 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1535020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5440166 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5409763 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5418843 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1444918 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1560937 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5424957 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5426834 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5408843 | — | IC50 | - | — | - | |
| CHEMBL5432782 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5402933 | — | IC50 | > | 100000.0 | nM | - |