Assay Detail
Functional
CHEMBL5355148
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Inhibition of thrombin induced platelet activation in CD-1 mouse plasma incubated for 2 mins by luminescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Plasma |
| Cell Type | Platelet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.20 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502016 | — | — | 1 | 8.15 |
| CHEMBL48361 | DABIGATRAN | 3.0 | 1 | 8.15 |
| CHEMBL5397791 | — | — | 1 | 5.36 |
| CHEMBL5421979 | — | — | 1 | 4.96 |
| CHEMBL5397575 | — | — | 1 | 4.37 |
| CHEMBL198362 | RIVAROXABAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502016 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL48361 | DABIGATRAN | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5397791 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5421979 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5397575 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL198362 | RIVAROXABAN | EC50 | > | 10000.0 | nM | - |